Curious about how organs communicate alterations in nutrient supply I modelled this question in fruit flies. This led me to identify how fruit flies fat cells communicate, stored energy supplies, to brain circuits. Remarkably, the molecule used by fruit flies to perform this feat of inter-organ communication, is the same one we humans use to communicate our overall fat stores to our brain circuits. Having discovered that surplus signaling mechanisms in flies are evolutionarily conserved, my lab's goal is to understand how 'over-nutrition' causes systemic breakdown of energy metabolism.
Away from the bench, I am an amateur food enthusiast. I enjoy experimenting with new recipes and reviving traditional ones from southern India.
Ava Brent/ Staff Scientist
The broad focus of my research is the genetic and environmental influences that affect every facet of life, from embryonic development to adult homeostasis, from human disease to evolution. Working with a variety of invertebrate as well as vertebrate systems, I have considered a number of specific questions: What developmental processes underlie early embryonic patterning in insects, and how have these processes changed over the course of evolution? What are the mechanisms by which the various components of the vertebrate axial musculoskeletal system are specified and organized during development such that proper form and function are ensured? How did the vertebrate axial skeleton evolve from an invertebrate chordate ancestor?
In the Rajan lab, my focus is to understand how genetic and environmental inputs converge as an organism senses and responds to its internal and external environment in an effort to maintain energy homeostasis. What consequences arise when that maintenance program becomes dysfunctional? And, of particular interest to me, how are peripheral inputs received and interpreted by neural circuits, and then translated into systemic instructions that bring about physiologic change throughout the organism?
When I’m not thinking about such questions in the lab, I can be found playing and exploring with my two lively little boys.
Laura Holderbaum/ Lab Manager
My lab life began in 2006 as a research technician and lab manager for Dr. Nadia Dahmane at the Wistar Institute in Philadelphia, studying the role of ZNF238 in developing mouse brains. A move to Boston in 2009 landed me in the lab of Dr. Norbert Perrimon at Harvard Medical School where I spent 7 years juggling fruit flies, databases and administrative support for his group of more than 40 members.
I’m excited to be an inaugural member of the Rajan lab, and to contribute my varied skills to help build a strong and successful operation. Professionally, I am eager to get back to more hands-on science. Personally, I can’t wait to explore the beauty of the Pacific Northwest!
When I'm not at the bench or at the computer, I enjoy wandering around and taking photos of graffiti and urban treasures.
Zach Goldberg/ Research Technician
My research career began as an undergrad at the University of Washington, where I graduated in 2016 with a B.S in Molecular, Cellular, and Developmental Biology. There, as part of the Ruohola-Baker Lab, I investigated mechanisms of stem cell regeneration in the Drosophila germline following irradiation , co-authoring a paper of our findings (10.7554/eLife.27842).
I’m excited to continue my work with fruit flies with the Rajan lab as a Tech; I’m particularly attached to this model system because of the plethora of genetic tools available to ask important questions about basic biology with implications for human health. Investigating metabolic dysfunction and over-nutrition provides me an excellent opportunity to hone my benchtop skills and further my knowledge of the underlying science.
Born in Chicago and raised in Little Rock, AR, I remain a huge fan of Chicago sports, especially the Cubs. Outside of work I enjoy reading, watching baseball, golf, playing guitar, video games, and riding my bike.
Michelle Poling/ Research Technician
During my undergraduate studies at the University of California, Davis, where I graduated in 2017 with a B.S. in Biotechnology, I focused on the idea of using biological systems to create products. Working in Dr. Justin Siegel’s lab I designed plasmids with specific mutations that when transformed into bacterial cells would result a multitude of different physiological changes such as in enzymatic activity, thermostability etc.,
I am eager to take the molecular biology skills I have learned in my previous lab experiences and apply them here at the Rajan lab. Attempting to answer the fundamental questions surrounding why metabolic disorders occur is something that hits close to home for many people, myself included. I am passionate about the problems we are trying to solve and excited to make an impact.
Originally from California, I love rooting for the Giants during baseball season. When I’m not on the bench, I can be found playing tennis, watching movies, and practicing photography.